| Airline | Model | # Operated |
|
| AeroMexico | 757-200 | 8 |
 |
| America West Airlines | 757-200 | 13 | |
| American Airlines | 757-200 | 151 | |
| Avianca | 757-200 | 6 | |
| British Airways | 757-200 | 15 | |
| Continental Airlines | 757-200/300 | 47 | |
| Delta Airlines | 757-200/300 | 129 | |
| El Al Israel Airlines | 757-200/300 | 5 | |
| Finnair | 757-200 | 6 | |
| Iberia Airlines of Spain | 757-200 | 15 |
|
| Mexicana Airlines | 757-200 | 9 | |
| Northwest Airlines | 757-200/300 | 65 | |
| Royal Air Maroc | 757-200/300 | 2 | |
| United Airlines | 757-200 | 97 | |
| US Airways | 757-200 | 34 | |
|
Total
|
602 |